Comparison of Ligands in Palladium-Catalyzed Electrochemical Allyl 4-Pyridinylation

Authors

Weijie Ding, Department of Material Science and Technology, Taizhou University, Taizhou, China; School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
Chunhui Yang, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
Zhongtao Feng, School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore
Shirong Lu, Department of Material Science and Technology, Taizhou University, Taizhou, China
Xu Cheng, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

Document Type

Article

Corresponding Author(s)

Weijie Ding(wding@tzc.edu.cn);
Xu Cheng(chengxu@nju.edu.cn)

Abstract

4-CN-pyridine is a widely applied 4-pyridinylation reagent for diverse transformations. Conventionally, the reaction proceeds via an open-shell radical cross-coupling pathway. Following our previous study, in this work, we report the Pd-catalyzed allyl 4-pyrinylation reaction under electrochemical conditions. The reaction proceeds via radical-polar crossover pathway in which the role of phosphine ligand in reactivity and selectivity was extensively investigated.

Graphical Abstract

Keywords

Electrochemistry, Palladium, Phosphine, Pyridinylation, Allyl

DOI

10.61558/2993-074X.3438

Online Date

12-24-2023

Recommended Citation

Weijie Ding, Chunhui Yang, Zhongtao Feng, Shirong Lu, Xu Cheng. Comparison of Ligands in Palladium-Catalyzed Electrochemical Allyl 4-Pyridinylation[J]. Journal of Electrochemistry, doi: 10.61558/2993-074X.3438.