4-CN-pyridine is a widely applied 4-pyridinylation reagent for diverse transformations. Conventionally, the reaction proceeds via an open-shell radical cross-coupling pathway. Following our previous study, in this work, we report the Pd-catalyzed allyl 4-pyrinylation reaction under electrochemical conditions. The reaction proceeds via radical-polar crossover pathway in which the role of phosphine ligand in reactivity and selectivity was extensively investigated.
Electrochemistry, Palladium, Phosphine, Pyridinylation, Allyl
Weijie Ding, Chunhui Yang, Zhongtao Feng, Shirong Lu, Xu Cheng. Comparison of Ligands in Palladium-Catalyzed Electrochemical Allyl 4-Pyridinylation[J]. Journal of Electrochemistry, doi: 10.61558/2993-074X.3438.