Abstract
4-CN-pyridine is a widely applied 4-pyridinylation reagent for diverse transformations. Conventionally, the reaction proceeds via an open-shell radical cross-coupling pathway. Following our previous study, in this work, we report the Pd-catalyzed allyl 4-pyrinylation reaction under electrochemical conditions. The reaction proceeds via radical-polar crossover pathway in which the role of phosphine ligand in reactivity and selectivity was extensively investigated.
Graphical Abstract
Keywords
Electrochemistry, Palladium, Phosphine, Pyridinylation, Allyl
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Date
2024-05-28
Online Available Date
2023-12-24
Revised Date
2023-09-04
Received Date
2023-08-14
Recommended Citation
Wei-Jie Ding, Chun-Hui Yang, Zhong-Tao Feng, Shi-Rong Lu, Xu Cheng.
Comparison of Ligands in Palladium-Catalyzed Electrochemical Allyl 4-Pyridinylation[J]. Journal of Electrochemistry,
2024
,
30(5): 2313003.
DOI: 10.61558/2993-074X.3438
Available at:
https://jelectrochem.xmu.edu.cn/journal/vol30/iss5/3
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