Comparison of Ligands in Palladium-Catalyzed Electrochemical Allyl 4-Pyridinylation

Authors

Wei-Jie Ding, a Department of Material Science and Technology, Taizhou University, Taizhou 318000, Zhejiang, China; b School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210023, Jiangsu, ChinaFollow
Chun-Hui Yang, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210023, Jiangsu, China
Zhong-Tao Feng, School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637371
Shi-Rong Lu, Department of Material Science and Technology, Taizhou University, Taizhou 318000, Zhejiang, China
Xu Cheng, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210023, Jiangsu, ChinaFollow

Corresponding Author

Wei-Jie Ding(wding@tzc.edu.cn); Xu Cheng(chengxu@nju.edu.cn)

Abstract

4-CN-pyridine is a widely applied 4-pyridinylation reagent for diverse transformations. Conventionally, the reaction proceeds via an open-shell radical cross-coupling pathway. Following our previous study, in this work, we report the Pd-catalyzed allyl 4-pyrinylation reaction under electrochemical conditions. The reaction proceeds via radical-polar crossover pathway in which the role of phosphine ligand in reactivity and selectivity was extensively investigated.

Graphical Abstract

Keywords

Electrochemistry; Palladium; Phosphine; Pyridinylation; Allyl

DOI Link

https://doi.org/10.61558/2993-074X.3438

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Date

2024-05-28

Online Available Date

2023-12-24

Revised Date

2023-09-04

Received Date

2023-08-14

Recommended Citation

Wei-Jie Ding, Chun-Hui Yang, Zhong-Tao Feng, Shi-Rong Lu, Xu Cheng. Comparison of Ligands in Palladium-Catalyzed Electrochemical Allyl 4-Pyridinylation[J]. Journal of Electrochemistry, 2024 , 30(5): 2313003.
DOI: 10.61558/2993-074X.3438
Available at: https://jelectrochem.xmu.edu.cn/journal/vol30/iss5/3