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Corresponding Author

Wei-Jie Ding(wding@tzc.edu.cn);
Xu Cheng(chengxu@nju.edu.cn)

Abstract

4-CN-pyridine is a widely applied 4-pyridinylation reagent for diverse transformations. Conventionally, the reaction proceeds via an open-shell radical cross-coupling pathway. Following our previous study, in this work, we report the Pd-catalyzed allyl 4-pyrinylation reaction under electrochemical conditions. The reaction proceeds via radical-polar crossover pathway in which the role of phosphine ligand in reactivity and selectivity was extensively investigated.

Graphical Abstract

Keywords

Electrochemistry, Palladium, Phosphine, Pyridinylation, Allyl

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Date

2024-05-28

Online Available Date

2023-12-24

Revised Date

2023-09-04

Received Date

2023-08-14

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