Electrochemically Induced Free Radical Polymerization of Methacrylic Acid and Fabrication of Amperometric Glucose Biosensor

Authors

Sheng WANG, Department of Chemistry ,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian,China;
Ying LEI, Department of Chemistry ,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian,China;
Kang SHI, Department of Chemistry ,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian,China;

Abstract

Electrochemically induced free radical polymerization of methacrylic acid was preliminarily investigated. Based on the electrochemical reduction of persulfate anion in phosphate buffer (pH 7.0) solution,the free radical polymerization of methacrylic acid was initiated to generate an ultrathin and biocompatible hydrogel layer on the gold electrode. At the meantime,glucose oxidase could be immobilized within the hydrogel film in the polymerization process. The resulting biosensor displayed an attractive performance.

Keywords

electrochemically induced, free radical polymerization, amperometric glucose biosensor, hydrogel layer, methacrylic acid

DOI Link

https://doi.org/10.61558/2993-074X.1990

Publication Date

2009-08-28

Online Available Date

2009-08-28

Revised Date

2009-08-28

Received Date

2009-08-28

Recommended Citation

Sheng WANG, Ying LEI, Kang SHI. Electrochemically Induced Free Radical Polymerization of Methacrylic Acid and Fabrication of Amperometric Glucose Biosensor[J]. Journal of Electrochemistry, 2009 , 15(3): 255-259.
DOI: 10.61558/2993-074X.1990
Available at: https://jelectrochem.xmu.edu.cn/journal/vol15/iss3/4

References

[1]Peppas N A,Hilt J Z,Khademhosseini A,et al.Hy-drogels in biology and medicine:from molecular princi-ples to bionanotechnology[J].Advance Material,2006,18:1345-1360.
[2]Lou X H,He P,Okelo G O,et al.Radical polymeriza-tion in biosensing[J].Anal Bioanal Chem,2006,386:525-531.
[3]Nagels LJ,Staes E.Polymer(bio)materials design for amperometric detection in LC and FIA[J].Trends in Analytical Chemistry,2001,20:178-185.
[4]Barlett P N,Cooper J M.Areviewof the immobilization of enzymes in electropolymerized films[J].Journal of Electroanalytical Chemistry,1993,362:1-12.
[5]Wang J.Electrochemical glucose biosensors[J].Chemical Reviews,2008,108:814-825.
[6]Hervás H,Prez J P,López M S,et al.Amperometric tyrosinase biosensor based on polyacrylamide microgels[J].Biosensors&Bioelectronics,2006,22:429-439.
[7]Guimard NK,Gomez N,Schmidt C E.Conducting pol-ymers in biomedical engineering[J].Progress in Poly-mer Science,2007,32(8/9):876-921.
[8]Yildiz G,Atalgi H C,Kadirgan L.Electrochemically prepared acrylamide N’N methylene bisacrylamide gels[J].Journal of Applied Electrochemistry,2000,30:71-75.
[9]Reuber J,Reinhardt H,Johannsmann D.Formation of surface-attached responsive gel layers via electrochemi-cally induced free-radical polymerization[J].Lang-muir,2006,22:3362-3367.
[10]Bunsow J,Johannsmann D.Production of polyacrylic acid homo-and copolymer films by electrochemically induced free-radical polymerization:preparation and swelling behavior[J].Macromolecule Symp,2007,370-381.