Corresponding Author

Jian-ying QU(lilyqujy@yahoo.com.cn)


The novel modified electrode was fabricated by electropolymerizing alizarin red onto the surface of multi-walled carbon nanotubes on glassy carbon electrode surface, which exhibited good electrocatalytic activity for folic acid. The experimental results showed that the reduction peak current of folic acid at -0.63 V was linear to its concentration over the range of 1.25×10-6 ~ 4.00×10-5 mol·L-1 in the optimized experimental conditions (R = 0.9985). Test for recovery was carried out by standard addition method, and the recovery ratios were in the range of 92.0% ~ 102.0%. The modified electrode was prepared simply with excellent stability, which provides a new feasible method for determination of folic acid.

Graphical Abstract


poly-alizarin red, multi-walled carbon nanotubes, folic acid

Publication Date


Online Available Date


Revised Date


Received Date



[1] Guo H X, Li Y Q, Fan L F, et al. Voltammetric behavior study of folic acid at phosphomolybdic-polypyrrole film modified electrode[J]. Electrochimica Acta, 2006, 51: 6230-6237.
[2] Ren C C(任超超),Sun Y Q(孙玉琴),Gao Z N(高作宁). Electrocatalytic oxidation of FA at multi-wall carbon nanotubes modified glassy carbon electrode and its electrochemical application[J]. Journal of Ningxia University(Natural Science Edition)(宁夏大学学报(自然科学版))[J]. 2010, 31(1): 70-73.
[3] Manoj D, Ranjith Kumar D, Santhanalakshmi J. Impact of CuO nanoleaves on MWCNTs/GCE nanocomposite film modified electrode for the electrochemical oxidation of folic acid[J]. Applied Nanoscience, 2012, 2(3): 223-230.
[4] Tong C L(童成亮), Wu X Y(吴小英), Zhong H B(钟淮滨). Simultaneous determination of two components in enalapril maleate folic acid tablets by HPLC[J]. Chinese Pharmaceutical Journal(中国药学杂志), 2006, 41(15): 1181-1183.
[5] Sun C Y(孙春燕), Zhao H C(赵慧春), Ou Y J(欧阳津). Determination of folic acid by flow injection chemiluminescence[J]. Method Chinese Journal of Analysis Laboratory(分析试验室)[J]. 2000, 19(3): 60-62.
[6] Liu B S(刘保生), Wang Y K(王云科), Zhang Y Q(张彦青). Determination of folate by lanthanide sensitized fluorescence quenching on terbium-ciprofloxacin[J]. Chinese Joumal of Analytical Chemistry(分析化学)[J], 2007, 35(7): 1067-1070.
[7] Shi H (施卉), Qiu L Y(邱利焱), Jin Y(金一), et al. Determination of the contents of water-soluble vitamin for injection by HPLC[J]. Chinese Pharmaceutical Journal(中国药学杂志)[J]. 2007, 42(19): 1501-1504.
[8] Wei S H, Zhao F Q, Xu Z Y, et al. Voltammetric determination of folic acid with a multi-walled carbon nanotube-modified gold electrode[J]. Microchimica Acta, 2006, 152(3/4): 285-290.
[9] Zhang B, Liang J, Xu C L, et al. Electricdouble-layer capacitors using carbon nanotube electrodes and organic electrolyte[J]. Materials Letters, 2001, 51(6): 539-542.
[10] Nugent J M, Santhanam K S V, Rubio A, e t al. Fast electron transfer kinetics on multiwalled carbon nanotube microbundle electrodes[J]. Nano Letters, 2001, 1(2): 87-91.
[11] Wang S M(王淑敏), Li Z S(李照山), Qu J Y(屈建莹). Voltammetric determination of chloramphenicol using glassy carbon electrode modified with multi-wall carbon nanotubes[J]. Chemical Research(化学研究)2007, 18(3): 83-86.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.