Determination of Tetracyclines Based on the Flow-through Electrochemical Detection Cell with Nickel Electrode

Authors

Dan-mei PAN, Department of Chemistry and the MOE Key Laboratory of Analytical Sciences,Xiamen University,Xiamen 361005,Fujian,China,;
Rong-zong HU, Department of Chemistry and the MOE Key Laboratory of Analytical Sciences,Xiamen University,Xiamen 361005,Fujian,China,;
Dong-ping WEI, Department of Chemistry and the MOE Key Laboratory of Analytical Sciences,Xiamen University,Xiamen 361005,Fujian,China,;College of Chemistry and Ecological Engineering,Guangxi University for Nationalities,Nanning 530006,Guangxi,China;
Hao-dong DING, Department of Chemistry and the MOE Key Laboratory of Analytical Sciences,Xiamen University,Xiamen 361005,Fujian,China,;

Abstract

The electrochemical responses to tetracycline at the nickel electrode in alkaline solution were compared with that of gold and glassy carbon electrode by voltammetry.The electrocatalytic oxidation characteristics of tetracycline at nickel electrode were discussed.Subsequently a flow-through amperometric detection cell with nickel as the working electrode was designed to detect tetracycline,oxytetracycline,and doxycycline.Standard calibration graphs for the tetracyclines yielded linear ranges of 0.1~15 mg/L.Detection limits(S/N=3)of 35,45 and 43 μg/L were obtained for tetracycline,oxytetracycline and doxycycline,respectively.The system was applied for the determination of the three antibiotics in single-component drug formulations.

Keywords

nickel electrode, tetracyclines, electrocatalytic oxidation, flow-through cell

DOI Link

https://doi.org/10.61558/2993-074X.1792

Publication Date

2007-05-28

Online Available Date

2007-05-28

Revised Date

2007-05-28

Received Date

2007-05-28

Recommended Citation

Dan-mei PAN, Rong-zong HU, Dong-ping WEI, Hao-dong DING. Determination of Tetracyclines Based on the Flow-through Electrochemical Detection Cell with Nickel Electrode[J]. Journal of Electrochemistry, 2007 , 13(2): 122-126.
DOI: 10.61558/2993-074X.1792
Available at: https://jelectrochem.xmu.edu.cn/journal/vol13/iss2/2

References

[1]El-Shafei A A.Electrocatalytic oxidation of methanol at a nickel hydroxide/glassy carbon modified electrode in alkaline medium[J].Electroanalytical Chemistry,1999,471:189.
[2]Sanit Palaharn,Orawon Chailapakul.Flow injection a-nalysis of tetracycline in pharmaceutical formulation with pulsed amperometric detection[J].Analytica Chimica Acta,2003,499:191.
[3]Hou Wei-Ying,Wang Er-Kang.Liquid chromatographic determination of tetracycline antibiotics at an electro-chemically pre-treated glassy carbon electrode[J].Ana-lyst,1989,114:699.
[4]Chen Mei-Cheng,Huang Hsuan-Jung.Application of a nickel-microelectrode-incorporated end-column detector for capillary electrophoretic determination of alditols and alcohols[J].Analytica Chimica Acta,1997,341(1):83.
[5]Liu You-Qin(刘有芹),Shen Han-Xi(沈含熙).Prep-aration of nickel hydroxide modified glassy carbon elec-trode and its electrochemical behavior[J].Journal of Analytical Science,2005,21(4):378.
[6]Wang Shen-Fu(王升富),Jiang Mian(蒋勉),Zhou Xing-Xiao(周性晓).The electrocatalytic oxidation of dopamine on nickel hexacyanoferrate flim modified elec-trode[J].Journal of Analytical Science,1994,10(1):15.
[7]Chai Li-Fen(蔡丽芬),Chen Yan-Zhen(陈衍珍),Gao Yuan-Zhong(高远忠).Studies on[Pt]-Ni(Ⅱ)electrode[J].Chemical Journal of Chinese Universi-ties,1991,12:1675.