Abstract
The applications of electrochemical methods in immunoassays and nucleic acid analyses are discussed. Instead of a comprehensive literature review, this paper focuses on the techniques that have already been commercialized and used in clinical diagnoses. Learning from the success of these methods will help us to further understand the strengths and limitations of electroanalytical technology. A personal perspective of the research and development in these fields has been presented.
Graphical Abstract
Keywords
electrochemical methods, immunoassay, nucleic acid analysis, clinical diagnostics
Publication Date
2017-04-28
Online Available Date
2017-04-28
Revised Date
2017-03-09
Received Date
2017-02-09
Recommended Citation
Yanbing Zu.
Electrochemical Methods in Clinical Immunoassays and Nucleic Acid Analyses[J]. Journal of Electrochemistry,
2017
,
23(2): 123-129.
DOI: 10.13208/j.electrochem.161248
Available at:
https://jelectrochem.xmu.edu.cn/journal/vol23/iss2/4
References
- Labib M, Sargent E H, Kelley S O. Electrochemical methods for the analysis of clinically relevant biomolecules[J]. Chemical Reviews, 2016, 116 (16): 9001-9090.
- Aoki H. Electrochemical label-free nucleotide sensors[J]. Chemistry-an Asian Journal, 2015, 10(12): 2560-2573.
- Bard A J. Electrogenerated Chemiluminescence [M]. New York: Marcel Dekker, 2004.
- Xu, X H N.; Zu Y B. Electrochemiluminescence detection in bioanalysis. In New Frontiers in Ultrasensitive Bioanalysis: Advanced Analytical Chemistry Applications in Nanobiotechnology, Single Molecule Detection, and Single Cell Analysis[M]. Xu, X-H.N., Ed.; New York: Wiley, 2007. 235-267.
- Richter M M. Electrochemiluminescence (ECL)[J]. Chemical Reviews, 2004, 104(6): 3003-3036.
- Miao W J. Electrogenerated chemiluminescence and its biorelated applications[J]. Chemical Reviews, 2008, 108(7): 2506-2553.
- Liu Z Y, Qi W J, Xu G B. Recent advances in electrochemiluminescence[J]. Chemical Society Reviews, 2015, 44(10): 3117-3142.
- Hesari M, Ding Z F. Review-Electrogenerated chemiluminescence: Light years ahead[J]. Journal of the Electrochemical Society, 2016, 163(4): H3116-H3131.
- Marcus R A. On the theory of chemiluminescent electron-transfer reactions[J]. The Journal of Chemical Physics, 1965, 43(8): 2654-2657.
- Zu Y B, Fan F R, Bard A J. Inverted region electron transfer demonstrated by electrogenerated chemiluminescence at the liquid/liquid interface[J]. The Journal of Physical Chemistry B, 1999, 103(30): 6272-6276.
- Defever T, Druet M, Evrard D, et al. Real-time electrochemical PCR with a DNA intercalating redox probe[J]. Analytical Chemistry, 2011, 83 (5): 1815-1821.
