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Abstract

The electrochemical behaviors of Actinomycin D(ACTD)at glod electrode were investigated by square wave stripping voltammeter in the KH2PO4-Na2HPO4 buffer solution(pH=5.90).The sensitive oxidation peak of ACTD was observed and the potential peak for ACTD is-0.17 V(vs.SCE).The Experimental parameters,such as pH value,amplitude,accumulation potential and time were optimized,and a direct electroanalytical method for determining ACTD was developed.The peak currents were proportional to the concentration of ACTD in the range of 0.1μmol·L-1~10.0μmol·L-1,and the linear regression coefficient equaled 0.9991.The detection limit for ACTD was 1.0×10-8mol·L-1.

Keywords

Actinomycin D, square wave stripping voltammeter, glod electrode, electroanalytical chemistry

Publication Date

2007-05-28

Online Available Date

2007-05-28

Revised Date

2007-05-28

Received Date

2007-05-28

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