Abstract
The electrochemical behavior of 6-furfurylaminopurine(6-KT) and 6-mercaptopurine(6-MP) on a mercury electrode has been investigated using cyclic voltammetry and differential pulse voltammetry.It is found that there are two pairs of redox waves for 6-KT and 6-MP on the mercury electrode controlled by diffusion and adsorption,respectively.The anodic peak currents of the diffusion-controlled wave increase with the adding concentration of 6-substituted purines.A good linear relationship for 6-KT and 6-MP is revealed in the concentration range from 0.1 to 50.0 μmol·L-1.Based on the effects of accumulating time and pH values on the cathodic peak potentials and currents of adsorption-controlled waves,their adsorption mechanism is discussed.The experimental results show that there are interactions of 6-KT and 6-MP with DNA via the intercalative mode partly and electrostatic action,respectively.
Keywords
6-furfurylaminopurine, 6-mercaptopurine, DNA, electrochemical behavior
Publication Date
2008-02-28
Online Available Date
2008-02-28
Revised Date
2008-02-28
Received Date
2008-02-28
Recommended Citation
Bao-yi LU, You-zhi ZHENG, Hong LI.
Electrochemical Behavior of 6-substituted Purines and its Interaction with DNA[J]. Journal of Electrochemistry,
2008
,
14(1): 34-39.
DOI: 10.61558/2993-074X.1859
Available at:
https://jelectrochem.xmu.edu.cn/journal/vol14/iss1/8
