The electrochemical behavior of 6-furfurylaminopurine(6-KT) and 6-mercaptopurine(6-MP) on a mercury electrode has been investigated using cyclic voltammetry and differential pulse voltammetry.It is found that there are two pairs of redox waves for 6-KT and 6-MP on the mercury electrode controlled by diffusion and adsorption,respectively.The anodic peak currents of the diffusion-controlled wave increase with the adding concentration of 6-substituted purines.A good linear relationship for 6-KT and 6-MP is revealed in the concentration range from 0.1 to 50.0 μmol·L-1.Based on the effects of accumulating time and pH values on the cathodic peak potentials and currents of adsorption-controlled waves,their adsorption mechanism is discussed.The experimental results show that there are interactions of 6-KT and 6-MP with DNA via the intercalative mode partly and electrostatic action,respectively.


6-furfurylaminopurine, 6-mercaptopurine, DNA, electrochemical behavior

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