Abstract
The linear sweep technique was used to study the electrochemical behavior of epirubicin hydrochloride.The results showed that there was a sensitive reduction peak at-0.34 V(vs.SCE) in pH 6.80 Tris-HCl buffer.When the BSA was added,the value of the reduction peak was reduced deeply.Accordingly,a new electrchemical determintation method of BSA was established.Under the optimum conditions,the decrease of the reduction peak currents of epirubicin hydrochloride were proportional to the concentrations of BSA in the range of 1.0×10-9～1.0×10-6 mol·L-1(R=0.9973).The detection limit of the BSA was 8.05×10-10 mol·L-1.And the binding constant β of the epirubicin hydrochloride and BSA was 3.04×106 L·mol-1 with the ratio of 1.
Keywords
epirubicin hydrochloride, bovine serum albumin(BSA), glassy carbon electrode
Publication Date
2011-02-28
Online Available Date
2011-02-28
Revised Date
2011-02-28
Received Date
2011-02-28
Recommended Citation
Hong-fen CHENG, Yong ZHANG, Jie-qiong SONG, Zeng-qiao WANG.
Interaction of the Epirubicin Hydrochloride with Bovine Serum Albumin and Its Application[J]. Journal of Electrochemistry,
2011
,
17(1): Article 15.
DOI: 10.61558/2993-074X.2820
Available at:
https://jelectrochem.xmu.edu.cn/journal/vol17/iss1/15
