Electrochemical Studies on Surface Inclusion of β-Cyclodextrin with Adriamycin

Authors

Jian SHI
Qi-Ping ZHANG
Nan-Ping WANG

Corresponding Author

Nan-Ping WANG

Abstract

The β-cyclodextrin (β-CD) modified gold electrode (β-CD/Au) was fabricated to study the electrochemical behavior of adriamycin (ADM). The results indicated that the complexing reaction of ADM with β-CD took place at the β-CD/Au surface. At 25 ℃，the complexing constant (K) was 9.54×104 L?mol-1 in pH=7.0. The K values changed regularly with temperature, and the most suitable temperature of the surface inclusion reaction was 30 ℃. The complexing reaction of ADM with β-CD at the β-CD/Au surface could undergo the quasi-reversible electrochemical reaction with the rate constant being 0.0995 s-1. The cathodic peak current (Ip) of ADM was proportional to the concentration of ADM in the 20~40 μmol?L-1. The linear regression equation for the quantitative determination of ADM concentration (C) by β-CD/Au was Ip=2.024+0.0057C with a correlation coefficient of 0.9911. The detection limit was 6.5 μmol?L-1.

Graphical Abstract

Keywords

adriamycin, β-cyclodextrin, modified electrode, complex

DOI Link

https://doi.org/10.61558/2993-074X.2867

Publication Date

2011-11-28

Online Available Date

2011-09-29

Revised Date

2011-08-01

Received Date

2011-07-08

Recommended Citation

Jian SHI, Qi-Ping ZHANG, Nan-Ping WANG. Electrochemical Studies on Surface Inclusion of β-Cyclodextrin with Adriamycin[J]. Journal of Electrochemistry, 2011 , 17(4): Article 14.
DOI: 10.61558/2993-074X.2867
Available at: https://jelectrochem.xmu.edu.cn/journal/vol17/iss4/14