Electrochemical Sensing of Guanine and Adenine Based on the Boron-doped Carbon Nanotubes Modified Electrode

Authors

Ya-Lin XIA, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
Chun-Yan DENG, Key Laboratory of Resources Chemistry of Nonferrous Metals, Central South University, Changsha 410083, China;
Juan XIANG, Key Laboratory of Resources Chemistry of Nonferrous Metals, Central South University, Changsha 410083, China;

Corresponding Author

Chun-Yan DENG

Abstract

In this work, the boron-doped carbon nanotubes (BCNTs) modified glassy carbon (GC) electrode was simply fabricated, and the electrochemical oxidation behaviors of guanine and adenine at the BCNTs/GC electrode were investigated. Compared with the bare GC and CNTs/GC electrodes, the BCNTs-modified electrode exhibited extraordinary electrocatalytic activity towards the oxidations of guanine and adenine as indicated by the obvious increase in current responses. Moreover, the peak separation between guanine and adenine was large enough for their potential recognition in mixture without any separation or pretreatment. Therefore, the simultaneous determination of guanine and adenine was successfully achieved. The BCNTs/GC electrode showed high sensitivity, wide linear range and low detection limit for the electrochemical determination of guanine and adenine. The possibility of the BCNTs/GC electrode for the determination of guanine and adenine in calf thymus DNA has also been evaluated. The BCNTs/GC electrode has advantages of excellent catalytic activity, selectivity and simplicity, which play a potential role in the development of the related DNA analysis.

Graphical Abstract

Keywords

boron-doped carbon nanotubes, guanine, adenine

DOI Link

https://doi.org/10.61558/2993-074X.2932

Publication Date

2012-08-28

Online Available Date

2012-04-20

Revised Date

2012-04-15

Received Date

2012-03-15

Recommended Citation

Ya-Lin XIA, Chun-Yan DENG, Juan XIANG. Electrochemical Sensing of Guanine and Adenine Based on the Boron-doped Carbon Nanotubes Modified Electrode[J]. Journal of Electrochemistry, 2012 , 18(4): Article 15.
DOI: 10.61558/2993-074X.2932
Available at: https://jelectrochem.xmu.edu.cn/journal/vol18/iss4/15