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Abstract

In 0.1 mol·L -1 NH 3 NH 4Cl buffer solution(pH 9.2),a sensitive reduction peak of complex of ciprofloxacin (CPFX) with manganese (Mn) was obtained by single sweep oscillopolarograph. The peak potential( Ep ) is -1.61 V(vs.SCE). The peak current ( i p) is proportional to the concentration of Mn(Ⅱ) over the range of 5×10 -6 ~2×10 -5 mol·L -1 . It is possible to be applied to the determination of Mn(Ⅱ). The polarographyic and voltammetric behaviour of complex was studied in detail. The ratio of CPFX∶Mn in the complex was 2∶1. The electrode reaction mechanism was discussed.

Keywords

Ciprofloxacin, Mn(Ⅱ), Complex, Polarography, Voltammetry, Reduction mechanism

Publication Date

1996-05-28

Online Available Date

1996-05-28

Revised Date

1996-05-28

Received Date

1996-05-28

References

1DannaLRoss,ChristopherMRilry.PhysicochemicalpropertiesofthefluoroquinoloneantimicrobialsV.EfectoffluoroquinolonestructureandpHonthecomplexationofvariousfluoroquinoloneswithmagne-siumandcalciumions.InternationalJournalofPharmaceutics,1993,93:121~1292LiRonaldCetal.Interactionbetweenciprofloxacinandmetalcation:Itsinfluenceonphysicochemicalcharacteristicsandantibacterialactivity.PharmRes,1994,11(6):9173AlenJBard,LarryRFaulkner.ElectrochemicalMethods(FundamentalsandApplications).JohnWiley&Sons,Inc.1980:96,1714AnsonF讲授,黄慰曾等译.电化学和电分析化学.北京:北京大学出版社,1983:465高小霞.极谱催化波.北京:科学出版社,1991:1526姚修仁,张立群.极谱催化波图谱.北京:地质出版社,1988:18

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