A Sensitive and Label-Free Electrochemical Aptasensor based on Signal Amplification of Carbon Nanotubes

Authors

Chun-yan DENG, College of Pharmacy, Central South University, Changsha 410083, China;College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China;
Hui-min FAN, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China;
Juan XIANG, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China;
Yuan-jian LI, College of Pharmacy, Central South University, Changsha 410083, China;Follow

Corresponding Author

Yuan-jian LI(yuan_jianli@yahoo.com)

Abstract

A label-free electrochemical sensing electrode for highly sensitive detection of adenosine was constructed based on the signal amplification of carbon nanotubes (CNTs). The change in the interfacial feature of the modified electrode was characterized by electrochemical impedance spectroscopy. Using [Ru(NH₃)₆]³⁺ as the signaling moiety, adenosine with concentrations as low as 0.027 nmol·L^-1 can be selectively detected. Additionally, the fabrication of this present aptasensor was simple, time-saving and cost-effective. Compared with other reported aptasensors, the proposed aptasensor had advantages of excellent sensitivity, selectivity and simplicity, which plays a potential role in development of aptasensor.

Graphical Abstract

Keywords

carbon nanotubes, aptamer, label-free, adenosine

DOI Link

https://doi.org/10.13208/j.electrochem.131161

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Date

2014-08-28

Online Available Date

2014-04-15

Revised Date

2014-04-09

Received Date

2013-11-26

Recommended Citation

Chun-yan DENG, Hui-min FAN, Juan XIANG, Yuan-jian LI. A Sensitive and Label-Free Electrochemical Aptasensor based on Signal Amplification of Carbon Nanotubes[J]. Journal of Electrochemistry, 2014 , 20(4): 386-391.
DOI: 10.13208/j.electrochem.131161
Available at: https://jelectrochem.xmu.edu.cn/journal/vol20/iss4/15