Corresponding Author

Jian-ding QIU(jdqiu@ncu.edu.cn)


Surface molecularly imprinted magnetic nanoparticles (NPs) were prepared by employing dopamine (DA) as a functional monomer, hemoglobin (Hb) as a template, H2PtCl6 as an oxidant triggered DA polymerization on the surface of the Fe3O4 NPs. The Hb and the formed platinum nanoparticles (PtNPs) were embedded into the polydopamine (PDA). After removal of the Hb, the surface molecularly imprinted magnetic nanoparticles (imprinted Fe3O4/PDA-PtNPs) were formed, and then simply immobilized on the magnetic glassy carbon electrode (imprinted Fe3O4/PDA-PtNPs/MGCE) for Hb sensing. The imprinted Fe3O4/PDA-PtNPs were demonstrated magnetic spherical shape with good solubility in water and narrow size distribution. The PtNPs embedded in the imprinted coating could effectively promote the conductivity and the mechanical strength of imprinted cavity. In addition, the imprinted Fe3O4/PDA-PtNPs/MGCE could selectively recognize Hb and was used to detect Hb in the range of 0.14 ~ 2.7 μg?mL-1 with a detection limit of 0.05 μg?mL-1 (S/N=3).

Graphical Abstract


molecularly imprinted polymer, magnetic nanoparticles, dopamine, hemoglobin, electrochemical sensor

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