Electrochemiluminescence Biosensors Based on the Signal Amplification of Co-reactants

Authors

Hai-jun WANG, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;
Li-juan XIAO, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;
Ying HE, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;
Xin-ya JIANG, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;
Ya-li YUAN, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;
Ying ZHUO, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;
Ya-qin CHAI, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;
Ruo YUAN, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;Follow

Corresponding Author

Ruo YUAN(yuanruo@swu.edu.cn)

Abstract

Using co-reactants to enhance the luminous efficiency of luminophores is a common, convenient and effective method in the construction of the electrochemiluminescence (ECL) biosensors. However, the different methods of introducing co-reactants in the construction of the ECL biosensors will bring different amplification effects. In this review, several signal amplification methods through co-reactants are summarized: 1) Adding the co-reactants directly into the detection solution; 2) Immobilizing the co-reactants onto the electrode surface; 3) Using enzymatic reaction to generate co-reactants in situ around the electrode surface. And then, the outlook of the ECL signal amplification strategy is proposed on those bases.

Graphical Abstract

Keywords

electrochemiluminescence, co-reactants, amplification, biosensors

DOI Link

https://doi.org/10.13208/j.electrochem.140439

Publication Date

2015-02-28

Online Available Date

2014-09-27

Revised Date

2014-09-22

Received Date

2014-07-23

Recommended Citation

Hai-jun WANG, Li-juan XIAO, Ying HE, Xin-ya JIANG, Ya-li YUAN, Ying ZHUO, Ya-qin CHAI, Ruo YUAN. Electrochemiluminescence Biosensors Based on the Signal Amplification of Co-reactants[J]. Journal of Electrochemistry, 2015 , 21(1): 13-21.
DOI: 10.13208/j.electrochem.140439
Available at: https://jelectrochem.xmu.edu.cn/journal/vol21/iss1/3