Rational Design of Electrochemical Molecular Probes for Highly Selective and Long-Term Measurement In Vivo

Authors

Yue Wang, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.;
Li-Min Zhang, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.;Follow
Yang Tian, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.;Follow

Corresponding Author

Li-Min Zhang(lmzhang@chem.ecnu.edu.cn);
Yang Tian(ytian@chem.ecnu.edu.cn)

Abstract

Designing electrochemical interfaces for in vivo analysis of neurochemicals with high selectivity and long-term stability is vital for monitoring dynamic variation and dissecting the complex mechanisms of pathogenesis in living animals. This review focuses on the development of electrochemical interfaces based on rational design of molecular probes for in vivo measurement with high selectivity and high stability from three aspects: (1) Specific recognition probes were rationally designed and created to remarkably improve the selectivity of in vivo analysis in a complicated brain environment. (2) The Au-C≡C functionalized surface was developed to remarkably enhance the stability of molecular assembly, and employed for real-time mapping and accurate quantification in the brains. (3) Combined with the Au-C≡C functionalized molecular probe, the new type anti-biofouling microfiber array was established to achieve long-term and real-time monitoring dynamic changes in the brain. At last, some perspectives are highlighted in the further development of the efficient electrochemical interfaces for in vivo detection in the brain.

Graphical Abstract

Keywords

electrochemical interface, recognition molecule, high stability, in vivo, brain

DOI Link

https://doi.org/10.13208/j.electrochem.210845

Publication Date

2022-03-28

Online Available Date

2021-12-18

Revised Date

2021-12-04

Received Date

2021-10-06

Recommended Citation

Yue Wang, Li-Min Zhang, Yang Tian. Rational Design of Electrochemical Molecular Probes for Highly Selective and Long-Term Measurement In Vivo[J]. Journal of Electrochemistry, 2022 , 28(3): 2108451.
DOI: 10.13208/j.electrochem.210845
Available at: https://jelectrochem.xmu.edu.cn/journal/vol28/iss3/8