Metal-Organic Frameworks for Electrochemical and Electrochemiluminescent Immunoassay

Authors

Xiao-Li Qin, College of Chemistry and Material Science, Hunan Agricultural University, Changsha 410128, China; Department of Chemistry, Western University, London, ON, N6A 5B7, CanadaFollow
Zi-Ying Zhan, Department of Chemistry, Western University, London, ON N6A 5B7, Canada
Sara Jahanghiri, Department of Chemistry, Western University, London, ON N6A 5B7, Canada
Kenneth Chu
Cong-Yang Zhang, Department of Chemistry, Western University, London, ON N6A 5B7, Canada
Zhi-Feng Ding, Department of Chemistry, Western University, London, ON N6A 5B7, CanadaFollow

Corresponding Author

Xiao-Li Qin (qinxl@hunau.edu.cn);
Zhi-Feng Ding (zfding@uwo.ca)

Abstract

Development of ultrasensitive, highly accurate and selective immunosensors is significant for the early diagnosis, screening, and monitoring of diseases. Electrochemical and electrochemiluminescent (ECL) immunoassays have both attracted great attention and become a current research hotspot due to their advantages such as good stability, high sensitivity and selectivity, wide linear range, and good controllability. Metal-organic frameworks (MOFs), as a new class of porous crystalline materials, have been widely applied in electrochemical and ECL immunosensors owing to their large specific surface area, good chemical stability, as well as adjustable pore size and nanoscale framework structures. Various MOF nanomaterials with different properties for the development of high-performance electrochemical and ECL immunosensors can be achieved, because they can be applied as sensitive platforms for immobilizing biological recognition molecules, enriching the trace analytes and signal molecules, amplifying the signal and enhancing the sensitivity of the electrochemical or ECL immunoassays. This review summarizes various types of MOFs-based immunosensors and their assays application, in which MOFs act as electrode matrices, signal probes (either as electroactive labels or as emitter labels), carriers or catalytic labels for sensitive electrochemical and ECL detections. Moreover, challenges and future opportunities for the development of the functionalized MOFs are discussed to provide a guidance on the design and fabrication of high-performance MOFs-based immunosensors in the future.

Graphical Abstract

Keywords

Metal organic frameworks; electrochemical immunosensors; electrochemiluminescent immunosensors; immunoassays

DOI Link

https://doi.org/10.13208/j.electrochem.2218003

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Date

2023-06-28

Online Available Date

2022-12-16

Revised Date

2022-12-02

Received Date

2022-11-12

Recommended Citation

Xiao-Li Qin, Zi-Ying Zhan, Sara Jahanghiri, Kenneth Chu, Cong-Yang Zhang, Zhi-Feng Ding. Metal-Organic Frameworks for Electrochemical and Electrochemiluminescent Immunoassay[J]. Journal of Electrochemistry, 2023 , 29(6): 2218003.
DOI: 10.13208/j.electrochem.2218003
Available at: https://jelectrochem.xmu.edu.cn/journal/vol29/iss6/10