Electrocatalytic Cyclopropanation of Active Methylene Compounds

Authors

Liang-Hua Jie, State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China
Hai-Chao Xu, State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, ChinaFollow

Corresponding Author

Hai-Chao Xu (haichao.xu@xmu.edu.cn)

Abstract

The development of novel strategies to access cyclopropanes has become increasingly important due to the vital role of these three-membered ring structures in synthetic intermediates, natural products, and pharmaceuticals. Herein, we present an electrocatalytic method for the synthesis of cyclopropanes through intermolecular dehydrogenative annulation of active methylene compounds and arylalkenes. This electrochemical process requires no chemical oxidants, allowing for a speedy access to various functionalized cyclopropanes from inexpensive and readily available materials.

Graphical Abstract

Keywords

Electrochemistry; Cyclopropane; Catalyst; Alkene; Organic electrosynthesis

DOI Link

https://doi.org/10.13208/j.electrochem.2313001

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Date

2024-04-28

Online Available Date

2023-07-11

Revised Date

2023-05-11

Received Date

2023-03-22

Recommended Citation

Liang-Hua Jie, Hai-Chao Xu. Electrocatalytic Cyclopropanation of Active Methylene Compounds[J]. Journal of Electrochemistry, 2024 , 30(4): 2313001.
DOI: 10.13208/j.electrochem.2313001
Available at: https://jelectrochem.xmu.edu.cn/journal/vol30/iss4/1