Study on Dopamine Electrochemical Sensing Basedon Au@MoS₂

Authors

An Ning, School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, 450001, China
Su Ni, School of Chemistry, Zhengzhou University, Zhengzhou, 450001, ChinaFollow
Xin Ran Li, School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, 450001, China
Wang Qi-Yan, School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, 450001, ChinaFollow
Liu Jian-Yu, School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, 450001, China

Corresponding Author

Su Ni (judy_sue@qq.com);
Wang Qi-Yan (wangqiyan_3@163.com)

Abstract

Dopamine (DA) is a vital neurotransmitter, and accurate detection of its concentration is critical for both clinical diagnostics and neuroscience research. Due to its electrochemical activity, DA is commonly detected using electrochemical methods, which are favored for their simplicity, fast response time, and suitability for in vivo analysis. In this work, a highly sensitive DA electrochemical sensor was developed using an Au@MoS₂ composite, created by modifying molybdenum disulfide (MoS₂) nanosheets with gold nanoparticles through HAuCl₄ reduction, and it was aimed at enhancing DA adsorption and improving detection performance. Scanning Electron Microscopy (SEM), transmission electron microscopy (TEM), Energy Dispersive Spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and X-ray Diffraction (XRD) confirmed the successful synthesis of Au@MoS₂ and the uniform distribution of gold nanoparticles across the MoS₂ nanosheets. Then, the electrochemical characterization demonstrated that the Au@MoS₂/GCE exhibited distinct oxidation peaks in a 10 μmol·L^–1 DA solution, with significantly enhanced electrochemical activity compared to both unmodified GCE and pristine MoS₂. Furthermore, differential pulse voltammetry (DPV) further revealed a strong linear relationship between DA concentration and the current response in the range of 800 nmol·L^–1 to 10 μmol·L^–1, with a low detection limit (LOD) of 78.9 nmol·L^–1 (S/N = 3). Additionally, the sensor showed excellent selectivity against other interfering substances. Moreover, the laser-induced Au@MoS₂ (LIAu@MoS₂), with its abundance of negatively charged surface defects, enabled the ultra-sensitive detection of the ultra-low concentrations of DA. In conclusion, the successfully fabricated Au@MoS₂ based sensor offers advantages such as low cost, ease of operation, and scalability, making it a promising candidate for biosensing applications due to its enhanced DA detection capabilities.

Graphical Abstract

Keywords

Dopamine; Electrochemical sensor; Molybdenum disulfide; Gold nanoparticles

DOI Link

https://doi.org/10.61558/2993-074X.3503

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Date

2025-03-28

Online Available Date

2024-10-24

Revised Date

2024-09-28

Received Date

2024-07-24

Recommended Citation

An Ning, Su Ni, Xin Ran Li, Wang Qi-Yan, Liu Jian-Yu. Study on Dopamine Electrochemical Sensing Basedon Au@MoS₂[J]. Journal of Electrochemistry, 2025 , 31(3): 2407241.
DOI: 10.61558/2993-074X.3503
Available at: https://jelectrochem.xmu.edu.cn/journal/vol31/iss3/3