In-situ Electrodeposition of FeCo-MOF on Au Ultramicroelectrode for Highly Sensitive Detection of Epinephrine

Authors

Chen Yan, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology,Anhui University, Hefei, 230601, P.R. China ; Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, 230601, P.R. China
Shang Jian, SINOCHEM International Advanced Materials (Hebei) CO., LTD. Technology Branch, Shijiazhuang, 050000, P.R. China
Wan Si-Yu, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China; Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, 230601, P.R. China
Cui Xiao-Tong, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China; Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, 230601,P.R. China
Liu Zhong-Gang, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China ; Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, 230601,P.R. China
Guo Zheng, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China ; Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, 230601,P.R. China

Corresponding Author

Zhong-Gang Liu (zhgliu@ahu.edu.cn); Zheng Guo (zhguo@ahu.edu.cn)

Abstract

Metal-organic framework (MOF) nanostructures have emerged as a prominent class of materials in the advancement of electrochemical sensors. The rational design of bimetallic MOF-functionalized microelectrode is of importance for improving the electrochemical performance but still in great challenge. In this work, the bimetallic FeCo-MOF nanostructures were assembled onto a gold disk ultramicroelectrode (Au UME, 5.2 μm in diameter) via an in-situ electrodeposition method, which enhanced the sensitive detection of epinephrine (EP). The in-situ electrodeposited FeCo-MOF exhibited a characteristic nanoflower-like morphology and was uniformly dispersed on the Au UME . The FeCo-MOF/Au UME demonstrated excellent electrochemical performance on the detection of EP with a high sensitivity of 36.93 μA·μmol^–1·L·cm^–2 and a low detection limit of 1.28 μmol·L^–1. It can be attributed to the nonlinear diffusion of EP onto the ultra-micro working substrate, coupled with synergistical catalytic activity of the bimetallic Fe, Co within MOF structure. Furthermore, the FeCo-MOF/ Au UME has been successful applied to the analysis of EP in human serum samples, yielding high recovery rates. These results not only contribute to the expansion of the research area of electrochemical sensors, but also provide novel insights and directions into the development of high-performance MOF-based electrochemical sensors.

Graphical Abstract

Keywords

FeCo-MOF; Gold disk ultramicroelectrode; In-situ electrodeposition; Electroanalysis; Epinephrine

DOI Link

https://doi.org/10.61558/2993-074X.3516

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Date

2025-03-26

Online Available Date

2024-12-31

Revised Date

2025-11-25

Received Date

2024-10-12

Recommended Citation

Chen Yan, Shang Jian, Wan Si-Yu, Cui Xiao-Tong, Liu Zhong-Gang, Guo Zheng. In-situ Electrodeposition of FeCo-MOF on Au Ultramicroelectrode for Highly Sensitive Detection of Epinephrine[J]. Journal of Electrochemistry, 2025 , 31(3): Article 5.
DOI: 10.61558/2993-074X.3537
Available at: https://jelectrochem.xmu.edu.cn/journal/vol31/iss3/5