Electrocatalytic Nanomaterials for Reduction of Hydrogen Peroxide as Potential Radioprotectors

Authors

Rui-hong JIA, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;Department of Pharmacy, Changzhi Medical College, Changzhi 046000, Shanxi, China;
Jin-xuan ZHANG, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
Xiao-dong ZHANG, Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China;
Mei-xian LI, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;Follow

Corresponding Author

Mei-xian LI(lmwx@pku.edu.cn)

Abstract

Nanomaterials have shown many potential application prospects in the biomedical field, such as medical imaging, drug delivery and biosensing due to their unique physical and chemical properties. In this review we focus on nanomaterials that have shown not only abilities of radiation protection, but also good electrocatalytic activities toward reduction reactions of hydrogen peroxide and oxygen. We discuss the abilities of radiation protection of these nanomaterials that are ascribed to their enzyme-like activities because their catalytic properties provide an effective pathway for scavenging free radicals in vivo via rapid reactions with reactive oxygen species. We also provide insights into electrocatalytic nanomaterials for the relationships between electrocatalytic activities and abilities of radiation protection that are critical for clinical translatability. Finally, we indicate current challenges and future directions in the possible use of these nanomaterials as novel radioprotectors for clinical translation as an adjuvant in radiotherapies.

Graphical Abstract

Keywords

nanomaterials, electrocatalysis, hydrogen peroxide, radioprotectors, reactive oxygen species

DOI Link

https://doi.org/10.13208/j.electrochem.181060

Publication Date

2019-06-25

Online Available Date

2019-04-09

Revised Date

2019-03-29

Received Date

2019-03-13

Recommended Citation

Rui-hong JIA, Jin-xuan ZHANG, Xiao-dong ZHANG, Mei-xian LI. Electrocatalytic Nanomaterials for Reduction of Hydrogen Peroxide as Potential Radioprotectors[J]. Journal of Electrochemistry, 2019 , 25(3): 340-348.
DOI: 10.13208/j.electrochem.181060
Available at: https://jelectrochem.xmu.edu.cn/journal/vol25/iss3/6